BMT is often preceded by high-dose chemotherapy, which destroys both your cancerous and healthy cells. Most patients will need to be in the hospital for three to four weeks after their transplant to avoid infection. Designed with input from BMT patients and their families, all rooms within this specialty care hospital are private, with space for family members and a restaurant-style meal service.
The BMT unit has a full-floor, pressurized, aseptic air-filtration system that allows patients freedom to leave their room, walk around, visit with family and friends, enjoy views of the terraced gardens and even work out in a special gym.
In certain situations, there are opportunities for some or even all of the transplant process to be performed on an outpatient basis. It also includes supporting you and your loved ones emotionally during your cancer journey.
Most of our support services are free. Studies show that the best patient outcomes occur in centers that perform a high volume of specific medical procedures, such as BMT. Data from our transplants are reported to the Center for International Blood and Marrow Transplant Research and the National Marrow Donor Program to track outcomes and compile other statistics that may improve survival, treatment, and quality life for transplant patients.
Agnes studied at home while taking care of her elderly parents. Doing the dishes Agnes noticed how oils and soaps could impact the surface tension of water. So, she invented a method of measuring that surface tension. She wrote a paper about her findings that was published in Nature , and went on to become a highly respected and honored pioneer in the field.
Their pioneering work showed how you could use CRISPR to make precise edits in genes, creating the possibility of using it to edit human genes to eliminate or cure diseases. In fact, some CIRM-funded research is already using this approach to try and cure sickle cell disease.
Appropriately enough none of that work would have been possible without the pioneering work of another woman, Barbara McClintock. She dedicated her career to studying the genetics of corn and developed a technique that enabled her to identify individual chromosomes in different strains of corn.
At the time it was thought that genes were stable and were arranged in a linear fashion on chromosomes, like beads on a string. It took a long time before the scientific world caught up with her and realized she was right.
But in she was awarded the Nobel Prize in Medicine for her work. Katherine Johnson is another brilliant mind whose recognition came later in life.
But when it did, it made her a movie star. Kind of. She did calculations by hand, enabling NASA to safely launch and recover astronauts in the early years of the space race. She was so highly regarded that when John Glenn was preparing for the flight that would make him the first American to orbit the earth he asked for her to manually check the calculations a computer had made. He trusted her far more than any machine.
There are so many extraordinary women scientists we could talk about who have made history. Jane Lebkowski with Regenerative Patch technologies and so many others. If you would like to learn about other women who have made extraordinary contributions to science you can read about them here and here and here.
Although the more commonly known symptoms involve respiratory issues, there have been other long term problems observed in recovered patients.
To better understand this, Dr. Tariq Rana and a team of researchers at the UC San Diego School of Medicine are using stem cells to create lung and brain organoids to better understand how the virus interacts with the various organ systems and to better develop therapies that block infection. Organoids are 3D models made of cells that can be used to analyze certain features of the human organ being modeled. Although they are far from perfect replicas, they can be used to study physical structure and other characteristics.
The team was surprised to see an approximately fold higher SARS-CoV-2 infection in lung organoids compared to brain organoids.
Besides differences in infection levels, the lung and brain organoids also differed in their responses to the virus. Rana elaborates on the results of his study. In different cell types, the virus triggers the expression of different genes, and we see different outcomes. The full results of this study can be found in Stem Cell Reports. No, me neither.
At least, not until yesterday when we held the first meeting of our Scientific Strategy Advisory Panel. This is a group that was set up as part of Proposition 14, the ballot initiative that refunded CIRM last November thanks again everyone who voted for that.
The idea was to create a panel of world class scientists and regulatory experts to help guide and advise our Board on how to advance our mission. You can see who is on the SSAP here. The meeting involved some CIRM grantees talking a little about their work but mostly highlighting problems or obstacles they considered key issues for the future of the field as a whole.
It started out innocently enough with Dr. Stem cells are the building blocks of multicellular life, and the intricate balance between proliferation and differentiation of a stem cell is essential during development and adulthood. CMM faculty members study a variety of stem cells including adult neural, epidermal, hematopoietic , embryonic, and induced pluripotent stem cells using functional genetics, genomics, and biochemistry approaches to understand the molecular mechanisms by which these cells make cell fate decisions.
Manipulation of stem cell fate holds great therapeutic promise in tissue engineering and regenerative medicine. Image: Tracking of human epidermal stem cells orange in regenerated human epidermal tissue grafted on immune compromised mice.
Courtesy George Sen. The goal of this symposium is to bring together stakeholders from academia, industry, government, and the public to discuss developments in the field for turning stem cell-based therapies into approved products for patients in need.
The program will highlight stem cell regeneration in several disease areas and interactive discussion panels regarding stem cells in space and stem cell clinical trials. Interested UCSD investigators, their research teams, academic collaborators, the scientific community, and the public are encouraged to attend. Email drmsyposium ucsd.
0コメント