Attenuation of rabies virus

The history of rabies research is itself pretty interesting. Georg Gottfried Zinke demonstrated that rabies was caused by an infectious agent. In , he showed that the disease could be passed from a rabid dog to a healthy one. Pasteur realized that if spinal cord samples from infected rabbits were air-dried, the virus contained in the samples became less virulent - attenuated, as it were.

This discovery prompted Pasteur to concoct the first rabies vaccine, and he showed it to be effective in dogs. Next, he turned it up to 11 by treating 9-year-old Joseph Meister. After a lengthy regimen of injections, the boy was declared healthy and rabies-free 3 months later.

Pasteur went on to treat some patients for rabies from Europe, Russia, and America. Login here. Register Free. Kerry Evans. Kerry received a doctorate in microbiology from the University of Arkansas for Medical Sciences.

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Abstract Gene expression of nonsegmented negative-strand RNA viruses is regulated at the transcriptional level and relies on the canonical 5'-end-dependent translation of capped viral mRNAs. Free full text. J Virol. Published online Dec PMID: Author information Article notes Copyright and License information Disclaimer. Phone: 49 89 Fax: 49 89 E-mail: ed. Received Sep 30; Accepted Nov This article has been cited by other articles in PMC. Go to:. Cells and viruses.

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